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KMID : 0390320110210020025
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Chungbuk Medical Journal
2011 Volume.21 No. 2 p.25 ~ p.33
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Prevalence of renal microtubular damage according to the cadmium level in human body
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Yim Dong-Hyuk
Moon Sun-In
Eom Sang-Yong
Kim Yong-Dae
Kang Jong-Won
Kim Heon
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Abstract
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Purpose: This study was performed to test whether the prevalence of cadmium-induced renal microtubular damage is increased in individuals who had been exposed to cadmium of high concentration.
Materials and Methods : Study subjects were 225 individuals (100 males and 125 females) who are living in an area which is highly contaminated with cadmium. We measured blood and urinary cadmium levels, urinary β2-microglobulin concentration, and urinary N-acetyl-β-D-glucosaminidase (NAG) activity, and tested statistical relationship between them.
Results: Blood cadmium and creatinine-adjusted urinary cadmium level were positively correlated with urinary β2-microglobulin level, but not with urinary NAG activity. Whereas, urinary cadmium level before the adjustment showed significant correlations not only with urinary β2-microglobulin level but also with urinary NAG activity. Distributions of subjects whose urianry β2-microglobulin concentration or urinary NAG activity was above normal were not significantly different among 3 groups classified by the blood cadmium level or by the creatinine-adjusted urinary cadmium level.
However, individuals with increased urinary NAG activity were more frequent in the group whose urinary cadmium concentration was bewteen 2 μg/L and 5 μg/L.
Conclusions: These results suggest that cadmium-induced microtubular damage persists after the drop of blood or urine cadmium concentration into normal range, and, therefore, markers of renal microtubular damage should be evaluated in persons whose blood or urine cadmium concentration is above 2 μg/L or 2 μg/g·creatinine.
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KEYWORD
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Cadmium, Microtubular damage, β2-Microglobulin, NAG
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